Sequence Input

Parameters

Contact

Email: basedesign@uq.edu.au

Github: https://github.com/BaseUQ/mRNArchitect

Example: For guidance on how to design an mRNA, please see the step-by-step example here

Sequences: Please find useful sequences (promoters, UTRs etc.) here

Input

Parameters

Results

References

  • Zulkower, V., & Rosser, S. (2020). DNA Chisel, a versatile sequence optimizer. Bioinformatics, 36(16), 2874-2875.
  • Sharp, P. M., & Li, W. H. (1987). The Codon Adaptation Index—a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Research 15(3), 1281-1295.
  • Lorenz, R., Bernhart, S. H., Höner Zu Siederdissen, C., Tafer, H., Flamm, C., Stadler, P. F., & Hofacker, I. L. (2011). ViennaRNA Package 2.0. Algorithms for Molecular Biology, 6(1), 26.
  • Mulroney, T.E., Pöyry, T., Yam-Puc, J.C. et al. (2024). N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. Nature 625, 189–194.